How is tension created and sustained in The Monkeys Paw Essay Example

How is tension created and sustained in The Monkeys Paw Paper The Monkeys Paw is a short, horror story written by WW Jacobs. It was written and set in the 19th century in a time where there was almost an obsession with the gothic, Victoria genre. Jacobs uses a range of techniques which create and add tension of the audience. The setting, structure, genre, characters, language and atmosphere all contribute to the ascending build up of tension throughout the story. The setting of the story is typical of the time in which it was set. There are many clues given by the author, which help us to distinguish the time period in which the play was set. Items such as the china candlestick and the fire would not be used commonly today because of the introduction of electrical heaters etc. Furthermore, when Mr white says: A rat. It passed me on the stairs, we find it difficult to comprehend this. This is because we would find a rat scuttling around in our houses today extremely peculiar and probably unbelievable whereas Mr and Mrs White do not seem to make much of a fuss about it because it may have been normal in that time. The rat may have been common then, in a time where plague and diseases were very active. We will write a custom essay sample on How is tension created and sustained in The Monkeys Paw specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on How is tension created and sustained in The Monkeys Paw specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on How is tension created and sustained in The Monkeys Paw specifically for you FOR ONLY $16.38 $13.9/page Hire Writer This all contributes towards the spooky/horror theme of the story which creates a feeling amongst the audience that they expect something to happen. The setting/atmosphere created in the story is very carefully thought out by the author. It starts with the father and son playing chess together, indicating that they have a close relationship and the family is close-knit. The family are in the warmth of their cosy home, at least the author gives this impression to us anyway, the fire burned brightly. Father and son were at chess. This image given to us by the author is very ironic because they may seem safe at the moment but later on we come to find out that they are far from it and are in fact extremely insecure. The weather is described to us as being, cold and wet, which has depressing, gloomy connotations which is therefore in complete contrast to the atmosphere inside. This signals a change in the plot, and the with the cold, wet weather, the author is almost hinting to use that something negative is going to happen in the story. Therefore, the reader is encouraged to read on because of the tension that has been created. However, the weather outside also reflects the mood of Mr. White who is upset after losing the chess match, so therefore it is pathetic fallacy, which in turn creates an eerie mood. Another significant factor in the setting of the story is Sergeant-Major Morriss introduction of India. Since India is a foreign country, the audience may not be so familiar with it. Therefore, they would not be too sure what to expect of the monkeys paw in terms of its powers and therefore mystery is created. This leads to the curiosity of the reader, creating tension as the reader gets eager and wants to know what will happen. The family live in a villa, away from everything, which gives us the impression they are isolated; Mr White says, Thats the worst of living so far out .. Only two houses in the road are let. This tells us that they live in a very secluded area, away from a town or city. By situating the family in this area, the author is hinting to us that something bad is going to happen because the thought of them with nobody else to help them if something goes wrong makes them seem vulnerable to us. Furthermore, Mr White saying to us that only two houses in the road are let enhances the idea that they are isolated because that means only two of the other houses are occupied. Sergeant-Major Morris is an extremely mysterious character. We seem to imagine him as a gigantic, mean, imposing, muscular man when hearing of his arrival because of the heavy footsteps, which he makes as described so by the author. His arrival is somewhat sprung on use and we do not get to know much about him until he starts conversing with the Mr White and family about the paw. Therefore he is almost like an unknown character to us. Once Mr White mentions the Monkeys Paw, he seems eager to change the subject: Nothing said the soldier hastily. This tells us that he was not keen to disclose information about the Monkeys Paw and was clearly hiding some details at the beginning. Once he realises the others are interested in the paw, he tries to play down its powers: its just an ordinary little paw dried to a little mummy. The reason for him acting this way is not clear to us at first but later on we get to know that the reason for this is because he has bad experiences with it. We know this because of his reaction when being asked is he had used his three wishes, his blotchy face whitened. This indicates that he has had some bad encounters with the paw because ones face usually whitens when feeling sick, shocked or frightened. However, he does warn the Whites about its powers, it has caused enough mischief already, although he prevents himself from revealing the full details of these events for some reason. It is also ironic that he says to the Whites, dont blame me for what happens, and but I warn you of the consequences, because although there are plenty of strong warnings, the Whites seem disinterested but in the end they pay for this i. e. Herberts death. On the whole, Sergeant-major is a mysterious character of whom we know little of. He seems to be hiding something about his experiences with the Paw. His character creates an eagerness in the audience resulting in tension. Another character who contributes to the tension created in the story is Mrs White. From what she says (her speech), we get to know that she is quite suspicious: He dont look to have taken much harm, is what she says when responding to something the sergeant said. This tells us she is not scared to point something out, and is prepared for an argument if she does not agree with somebody. It also tells us that she may know something about the sergeant that we do not. Similarly, she is very curious about the monkeys paw and is surprised upon hearing of its powers, Sounds like Arabian nights, she says. Here, she is mocking the sergeant major, making a mockery of a highly respected figure. It also tells us that she is a very curious person. This suspicious, curious attitude of hers adds to the tension. However, Mrs Whites attitude to the paw very much changes towards the end of the story. After learning about the death of her son, Herbert, she wants to bring him back by using the powers of the paw. This is in high contrast to her attitude at the beginning when she thought it was just a toy. She urges her husband to wish for Herbert back using the paw: Wish she cried in a strong voice. This tells us of her eagerness to bring Herbert back, indicating she loves her son very much. During the climax, the language devices and style used by the author are all very interesting, and were all created in order to create a rush of tension at the end. The sentences used at this point in the story are shorter ones in comparison to the more complex and compound sentences used beforehand. Sentences such as, His wife sat up in bed listening, Let go and I must open the door are use by the author in order to increase the pace of the story and to create anxiety amongst the audience. The sentences are short in order to delay the point of climax, so that the audience find the ending of a better quality. There are also short bursts of action at this point in the story to get the reader excited about what will happen, and frantically breathed his third and last wish. This is probably the part of the play where the tension is at its highest because the audience are holding their breath as to what it going to happen. The adverbs used by the author help to create this tension because words such as frantically, hoarsely and appealingly give us an insight to the actual feelings of the characters. This helps us because then we can relate to the characters. In conclusion, I can say that in the monkeys paw the author uses a variety of methods to create tension. These include characters, setting, structure, language and style. Overall, I would say that Sergeant-Major Morris is the person who contributes to providing the most amount of tension in the play. His mysteriousness and whole demeanour just makes the audience think that something bad is going to happen in the play because of him. I also think that the climax used by WW Jacobs was a very clever way to build up a lot of tension.

Starting a website with no fuss. Read all about it here

Starting a website with no fuss. Read all about it here How to start a website in 20 minutes Sometimes when we hear the word website most people take to their heels as they always imagine it must be something very complex. Well allow us to quickly show you how you can get your own website up working in no time and you do not need a web developer or designer for this. So you know just about anybody can start their own website. 5 reasons to start a website 1.  Ã‚  Ã‚   Boost your CV and boost your professional presence. 2.  Ã‚   If your reason for creating a website is to make money then you are on the right path. 3.  Ã‚   Presents you with more freedom and allows you to work from just about anywhere. 4.  Ã‚   Very easy and affordable. WordPress WordPress is a free Content Management System (CMS) that lets anyone create, design, write and manage their own website. Do not think just because of its free cost then it's not the real deal. Well so you know CNN, NASA all are using WordPress. Statistically, WordPress platform manages over 25% of all website present today. One more thing it is really beginner friendly. WordPress needs to be installed on a web host and in this article; we will be using Bluehost which is very easy to run. The cost of using Bluehost is very minimal. 1.  Ã‚  Ã‚   Choose and register a domain name The first thing you need to do is get a domain name. This is usually what people type on their browser to find your website. For example, savethestudent.org is a domain name. With a domain name, everyone who wants to check your website out can easily find it. We have different domain name extensions, .com, .net, .info, .org. We have special service providers that could easily get you any domain name for a low-cost if such name is available. Note sometimes you have to make multiple changes to a choice of name because you are just one person in a million trying to get a domain name registered. So if your name is not available all you need to do is make a twitch by adding a number (1†¦..) or a character (-) or you can try a different extension (.info). A little twitch to the name can be beneficial. 2.  Ã‚  Ã‚   Setup website hosting As mentioned earlier every website needs to be hosted. Do not be scared when you hear these names. Think of a web host as the house accommodating all websites. When any visitor types your domain name it’s the job of the web host to serve your website to be seen. There are loads of web hosting services out there but for the purpose of beginners, we suggest you use Bluehost.   6 main reasons for choosing Bluehost 1. it’s not expensive (from $2.95pm) 2. Trustworthy (99.9% uptime) 3. Free domain name, email addresses 1-click WordPress install 4. Very cool and effective support and guides. 5. 30-day full refund policy if services granted are not satisfactory. 6. WordPress recommended. Usually to get a good price you need to pay for about a year or more and this will result in you paying just a little fraction. 3.  Ã‚  Ã‚   Installing WordPress on Bluehost So now after the two steps above you already have an online presence but to have your website looking as it should be you need to download WordPress. Now you can add content and create your own design. There is no need for any formal education to be able to use this platform. Most of the tools you will need are already available to you inside. All you have to do is use what you want. Technically your online presence is secured at this stage, but if anyone goes over to your site, there won't be much to see! That won't be for long though†¦ you're about to install WordPress which allows you to easily manage your whole site, including content and design, without any technical background or coding experience. WordPress which was formally designed for blogs but now millions of websites use it with some very big names like CNN and MTV. 4.  Ã‚  Ã‚   Choose your WordPress theme If someone visits your website at this stage it still looks too basic and empty. So, it’s time to do some work. First, you change the theme of your website. This going to be the first page every visitor sees when they arrive on your page. There are loads of themes available for you to choose from. Get to the Admin panel click on Appearance Theme. After you see what you like you can first preview it to see how it looks or go ahead and install to apply the Theme. Adding contents is quite easy, click on â€Å"Posts" "Add New" will open up the editor window, which looks just like the typical word processor. As soon as you get some articles published on your website there can be an endless flow of audience to your website and this brings us to the one important thing to know. You need traffic and by this we mean people visiting your website. Of course, you now have a functioning website but what use will it be if no one visits it. With Face book, Twitter and other social platforms it’s quite easy to drive traffic to your website page.

Harley Davidson Cultural impact of media on women Research Paper

Harley Davidson Cultural impact of media on women - Research Paper Example People are easily updated with the happenings around them through those media as writers, bloggers, newscasters and columnists relay the information to the viewers. Sometimes those relayed information may not be the whole truth at all as sometimes works of fiction do affect the rituals and culture of people. Massive influence may be achieved through mass media and sometimes those become the avenue for negativities in the society to flourish. The widespread of the influence of the negative practices in the society may be attributed to the media that may be intentional or unintentional. It is considered as intentional when people truly want to influence others with their deeds and beliefs that may pose risks and hazards to the society and considered as crimes. Other activities that may be seen in media but are not considered crimes but may challenge the border that separates the morally acceptable beliefs and immoral ones. The cases that may arise from mass media that are in the bounda ry of right and wrong are the issues of gender and sexuality, abortion, euthanasia, divorce, no religious affiliation, and roles in the society. In particular, the paper will talk about the effects of media to the lives of women especially in the cultural aspect. Harley Davidson would be the subject for the media effects on women as that company endorses motorcycles and how it blends into the culture of women. Then several questions may have arisen from the motorcycle craze and its influence on the female gender. Does it make women more masculine? Does it encourage violence and other negativities in the society? What are its other impacts? Does motorcycle craze give any positive influence to the society as a whole? Will gender roles be greatly affected? The three previous studies about the effects on women would include â€Å"Girl Power† and Participation in Macho Recreation: The Case of Female Harley Riders by Catherine Roster, Subcultures of Consumption: An Ethnography of t he New Bikers by John Schouten and James McAlexander, and Examining Gender Images, Expectations, and Competence as Perceived Impediments to Personal, Academic and Career Development by Lorraine Wilgosh. The study of Roster talks about the women empowerment gained from the inclusion of some women in motorcycling sports which is played mainly by men. On the other hand, the study of Schouten and McAlexander goes into the culture of consumerism and an analysis was done on how it brings about the change in the society and behaviors of people especially for bikers. The last study was about the discrimination, stereotyping and societal imaging of what women should be and those effects upon the development of young girls. Other sources that will be used for the study are Older Women, Liberation and Lifestyles: Self-Care and Other Care, Depicting outlaw motorcycle club women using anchored and unanchored research methodologies, and Brand Morphing: Implications for Advertising Theory and Prac tice. Method The study was done by looking at the previous studies from background, methods to results, analysis and conclusion. It did not utilize primary sources and did not have any actual experimentation and first-hand data gathering as it relied purely on the theories and results laid down by the previous studies and reports. It made use of the six journal articles mentioned in the background section of the paper. Each source had its own contribution

Zappos Case Study Example | Topics and Well Written Essays - 250 words

Zappos - Case Study Example Customers are able to track the inventory of Zappos online. 2. Zappos creates superior customer experiences through do the unexpected. The company believes that customers who are shocked by the service that they receive will want to stay loyal to the brand for a long time. This also has a knock-on effect of picking up new customers who hear of the service quality offered by Zappos. Word-of-mouth marketing is an important tool that Zappos can use to attract new customers. 3. Quality management is an important part of the sales process for Zappos because the customer has a minimum demand for service. Zappos can only meet that demand by making sure that its customers are satisfied with the products they receive. Secondly, process design is also another important part of the service on offer because quality goods and services can only be offered to customers if the right inputs have been included in designing, procuring, and marketing the product or service effectively. Thirdly, service encounter design forms a crucial part of the Zappos experience because interactions between employees and customers can determine the success of the brand as a whole. Also, whenever a customer is not satisfied with the level of service shown by Zappos, the company needs to go beyond the normal level of service to regain the trust of the

Research Proposal Essay Example | Topics and Well Written Essays - 1500 words

Research Proposal - Essay Example In these regards, a strong degree of passenger involvement is financial reason enough to motivate both the rail system and the makers of the advertisements to develop the necessary infrastructure to support the process. While digital advertisements may be firmly entrenched in new media technology they must be more situated towards subjective viewer experience if they are to gain maximum interactivity. The research seeks to accomplish these objectives through an approach that combines investigation into past statistical research, direct action research that investigates the extent that participants engage with the advertisements compared to advertisements in a control group, and finally post-experiment interviews with the participants. III. Specific Research Questions Do digital (rather than static) advertisements on the tube increase patron interactivity and engagement? Were the digital advertisements at all disruptive to the transportation service? How did the added sound affect the ir experience in the tube? How could these digital advertisements be better structured to encourage optimum interaction? How did the digital advertisements made the participants emotionally feel? Did they feel more or less connected to the other passengers when the digital advertisements were in the tube? IV. ... From a purely infrastructure standpoint one recognizes that modern railway system emerged from earlier trains and much of the qualitative approach to infrastructure, in this instance print advertising appears to have been carried over from an earlier era and not enough consideration given to the increasing technological mediation of the modern world. In this regards the study design is aimed not only at determining the general effectiveness and best possible course of action of digital advertising displays, but also that it would financially benefit the rail system to implement these digital displays. V. Research Concepts One of the predominant considerations of the methodological approach is the extent that it responds to the notion of a third paradigm of human computer interaction research. Harrison & Sengers (2007) argue that human computer interaction research has previously focused on two paradigmatic models. The first model considered the development of technological interactio n in terms of man-machine coupling. The second wave paradigm built on this coupling, further considering the way that technological interaction constitutes a form of information communication. The third paradigm, they contend, considers technological interaction as phenomenological experience. Considered within the context of the previously established research methodology it’s clear there are many areas where the research fails to address the third paradigm of human computer interaction research. In some areas the methodology considers the third wave paradigm experience of digital advertising in the tube. One recognizes that the phenomenological means of interaction the current research refers to places great emphasis on the experience the user has with the technology.

Role of Exercise in Reducing Insulin Resistance

Role of Exercise in Reducing Insulin Resistance By: Pranav Maddali Abstract The major pathway of glucose regulation in the body is via the Glucose Transport System (GTS) in which cells stimulated by insulin cause an upregulation in expression and translocation of a glucose transporter protein, GLUT4, to the cell plasma membrane, resulting in increased glucose transport into the cell. Thus, insulin is directly responsible for regulating carbohydrate and fat metabolism in the body. However, increased dietary intake and the lack of physical exercise has been implicated in creating a condition known as insulin resistance, whereby the cells fail to uptake glucose in response to insulin stimulation, leading to hyperglycemia and significantly increasing the odds of acquiring insulin-dependent (Type-1) and non-insulin-dependent diabetes mellitus (Type-2). However, recent studies have shown that skeletal muscles, the major consumer of glucose in the body, possess an alternative mechanism to elicit glucose uptake using GLUT4 instead of insulin stimulation, which is tr iggered by exercise. This review elucidates glucose transport mechanisms in both normal and insulin resistance states and the role of physical exercise in potentially reversing insulin resistance and helping regulate blood glucose levels in diabetic patients. INTRODUCTION Glucose, Insulin, and the Glucose Transport System Glucose is one of the three dietary monosaccharides, along with fructose and galactose, which is directly absorbed into the bloodstream during digestion. This simple monosaccharide serves as both, the main substrate for energy production as well the precursor to the synthesis of many other carbon containing molecules in the body [1]. In relatively healthy individuals, following a meal, glucose absorbed from the gut during digestion stimulates the release of insulin, a peptide hormone, from pancreatic ÃŽÂ ²-cells. This results in glucose uptake by skeletal muscles and adipose tissues, promptly returning plasma glucose levels to the normal range (approximately 4.4-6.1 mM) [1]. During resting conditions, the absorbed glucose is stored as glycogen in the liver and skeletal muscles, and as triglycerides in adipose tissue [1]. In times of fasting or increased energy demand, these stores are quickly re-converted back to glucose and released into the blood stream, helping maintain homeostatic blood glucose concentrations. By promoting postprandial glucose uptake by muscle and adipose tissues via the Glucose Transport System (GTS) and suppressing hepatic glucose production, insulin is directly responsible for regulating carbohydrate and fat metabolism in the body [1-3]. Given that the cell membrane is impermeable to glucose, specific carrier proteins or transporters spanning the cell membrane allow the binding and uptake of glucose across the hydrophobic lipid bilayer. Mammalian cells possess two general classes of these carriers/transporters: 1) ATP-dependent Na+/glucose co-transporters that transport glucose against a concentration gradient and 2) facilitative glucose transporters which work in the direction of the glucose gradient [4, 5]. Following digestion, the Na+/glucose co-transporter transports glucose from the lumen of the intestine into polarized epithelial cells where subsequent facilitative transport of glucose moves glucose out of the intestinal epithelium and into the blood. Given that different tissues have different physiological energy needs, their uptake of circulating blood glucose is mediated by tissue-specific glucose transporter proteins called GLUTs [1, 4]. 14 different GLUTs have been identified in mammalian cells that are further divided into three subclasses on the basis of sequence similarities and biochemical properties, of which   the roles of GLUT1-GLUT4 in the GTS are the most well characterized [6, 7]. INSULIN-MEDIATED POSTPRANDIAL GLUCOSE TRANSPORT During resting conditions, GLUT1/3/5, constitutively localized to the cell plasma membrane, provide low-level of basal glucose uptake required to sustain respiration in all cells [1]. However, during postprandial conditions, high glucose in the blood stimulates the release of insulin from the ÃŽÂ ²-cells found in the Islets of Langerhans in the pancreas. This secreted insulin regulates the uptake of blood glucose in stimulated skeletal muscles and adipocytes by binding to the insulin receptor (IR) on the surface of the cell (Figure 1). Following insulin binding, the ÃŽÂ ²-subunit of IR undergoes autophosphorylation on tyrosine residues activating its tyrosine kinase activity. The activated IR then phosphorylates Insulin Receptor Substrates (IRS-1) which serves as a docking protein for Phosphatidylinositide 3-kinase (PI3K), activating it. The serine phosphorylation cascade initiated by PI3K activates PI3K-dependent serine/threonine kinases (PDK), which activates downstream Akt k inase, resulting in the translocation and exocytosis of intracellular GLUT4 vesicles to the cell surface. This upregulation of GLUT4 localization on the plasma membrane results in an increased rate of glucose transport into the cell [1, 4, 5, 8, 9]. The necessity of each of these activation steps has been established by in vitro studies on muscle and adipose tissue that used specific kinase inhibitors or mutant proteins and observed the complete ablation of the stimulatory effect of insulin on glucose uptake in insulin stimulated cells. Furthermore, the translocation of GLUT4 specifically in response to insulin approximately 1% pre- vs. almost 40% post-stimulation, suggests a mechanism of regulation to restrict glucose uptake during low-insulin states [1, 9]. Given that GLUT4 translocation is a critical regulatory site for glucose uptake, abnormal GLUT4 regulation in response to insulin stimulation can have a significant impact on glucose homeostasis in the body. Interestingly, recent studies have shown that mice fed with high caloric diets show significantly decreased glucose uptake in muscle and adipocytes despite stimulation with insulin [8, 10]. Further analysis revealed significant down regulation of PI3K and its downstream substrate PDK in addition to increased expression and activity of Protein Kinase C isoform theta (PKC-ÃŽÂ ¸) in these mice, suggesting impaired insulin mediated signaling and a direct co-relation with high caloric diets (red boxes/arrows in Figure 2) [8, 11-13]. This lack of response to insulin stimulation has long been implicated in the pathogenesis of Type-2 or Non-insulin dependent Diabetes Mellitus (NIDDM) and is commonly referred to as insulin resistance. INSULIN RESISTANCE FINDING A SWEET SOLUTION The term insulin resistance is used to describe a combination of a lack of insulin-mediated glucose uptake in cells stimulated by insulin and a defect in the ability of insulin to suppress hepatic glucose production; the former commonly attributed to dysregulation of GLUT4 trafficking [14]. Over time, together with reduction in in insulin secretion by the pancreas, these aberrations have been directly linked to causing Type-2 Diabetes mellitus (T2D). Diminished insulin function at sites of insulin action, such as skeletal muscles and adipocytes (insulin resistance) and a decrease in the ability of pancreatic ÃŽÂ ²-cells to secrete insulin in response to postprandial increase in blood glucose levels, are two hallmarks of   T2D [15]. In recent years, Type-2 Diabetes mellitus has emerged as one of the major non-communicable chronic diseases around the world [2]. According to the CDC, that number is currently estimated to be about 26 million in the US alone. Recent epidemiologic data point to excess caloric intake combined with increasingly sedentary lifestyles as factors significantly contributing to this trend [16]. Although both genetic and environmental factors have been implicated in causing these malfunctions, researchers have increasingly suggested that obesity, caused by a chronic imbalance between energy expenditure and energy intake, as one of biggest risk factors for developing insulin resistance and T2D [16]. Given that skeletal muscles constitute approximately 40% of human body mass and have relatively high energy requirements, they account for almost 50-75% of insulin-stimulated glucose uptake in the body [17]. Thus, skeletal muscle is considered the most important tissue with regards to insulin-stimulated blood glucose disposal, and correspondingly maintenance of glucose homeostasis, especially during postprandial periods. Interestingly, both in vitro and in vivo studies dating back to as early as 1987 have shown that in muscle cells, stimuli other than insulin can activate the glucose transport system, namely GLUT4 translocation, to a similar magnitude, albeit likely via a separate (insulin independent) signaling pathway [3, 9, 17]. Furthermore, while GLUT4 gene expression was reduced in adipose cells in insulin-resistant states such as obesity and NIDDM, skeletal muscle GLUT4 expression remained normal [9]. This finding prompted the thinking that insulin resistance in skeletal muscle is most likely due to alterations in the translocation, docking, or fusion of glucose transporters at the plasma membrane, and not defects at the transcription or translational levels. Additionally, researchers observed that in rodents, various modes of exercise and muscle contractile activity such as running exercises, swimming exercises, contraction of hind limb muscles via sciatic nerve stimulation, or contraction of isolated muscles, caused GLUT4 translocation in these skeletal muscles [18]. Additionally, similar studies published by the Goodyear, Holloszy, and Hargreaves groups over the past three years using human models have demonstrated that a single bout of exercise significantly increases glucose transport by upreguatling both GLUT4 expression and translocation in muscles, adding significant support to the hypothesis suggesting that exercise induced muscle contraction can improve glucose uptake by increasing both GLUT4 expression and translocation, potentially reversing the effects of insulin resistance and T2D [3, 5, 10].      Ã‚   WORKING THE GLUTs EXERCISE INCREASES GLUT4 TRANSLOCATION AND GLUCOSE TRANSOPORT Despite the fact that insulin stimulation and exercise-induced muscle contractile activity induce similar magnitudes of increases in muscle glucose transport via upregulation of GLUT4 vesicle translocation to the plasma membrane, the mechanisms of action of these two stimuli are very distinct [19, 20].Studies using cellular fractionation techniques have shown the presence of two distinct intracellular pools of sequestered GLUT4 vesicles, both containing the insulin-responsive amino peptidase (IRAP) and vesicle-associated membrane protein-2 (VAMP-2) that assist in in regulating endocytosis/exocytosis [20, 21]. However, the contraction stimulated GLUT4-vesicle pool was not recruited during insulin stimulation and the important components of the insulin signaling cascade IR, IRS-1, PI3K, etc., were not phosphorylated or activated by exercise [22-24]. Additionally, Wortmanin, a potent PI3K inhibitor, did not inhibit glucose transport stimulated by muscle contraction as it does the insul in-stimulated pathway, clearly indicating the presence of a distinct pathway [24]. Intracellular calcium, 5AMP-activated protein kinase (AMPK), nitric oxide (NO), and mitogen activated protein kinase (MAPK) p38, have been implicated regulating GLUT4 translocation in the exercise-medicated effect, although the exact mechanism of how each of these exerts its influence is currently being explored (Figure 3) [9]. These acute effects of exercise, in conjecture with dietary restrictions and pharmaceutical interventions, can and are currently exploited by individuals and pharmaceutical companies in an attempt find a cure to insulin resistance and T2D. Although the mechanism of how chronic exercise training improves insulin sensitivity is unclear, muscle levels of GLUT4 as well as the activity of glycogen synthase have been shown to be elevated in athletes compared to sedentary controls with muscle GLUT4 expression increasing in individuals who exercise regularly[25]. This likely due to the fact that many genes involved in carbohydrate metabolism (hexokinase, GLUT-4) appear to be jointly upregulated together with mitochondrial enzymes in response to increased muscle contractile activity [10, 18, 19, 22] . CONCLUSIONS The recent drastic increase in the prevalence of T2D has been attributed mainly to decreased levels of physical activity and increased caloric intake. Several studies discussed in this paper have shown that higher levels of habitual physical activity results in increased glucose uptake in skeletal muscles via an insulin-independent mechanism. Furthermore, regular exercise has also been shown to improve insulin sensitivity and glucose uptake in subjects with insulin resistance and T2D. Thus, regular exercise together with diet and weight control, could be the answer to overcoming insulin resistance and significantly reducing the risk of acquiring Type-2 diabetes, and in turn decreasing the odds of developing dilapidating conditions such as atherosclerosis, glaucoma, and stoke.   References 1. Bogan, J.S. (2012). Regulation of glucose transporter translocation in health and diabetes. Annual review of biochemistry 81, 507-532. 2. Oliveira, C., Simoes, M., Carvalho, J., and Ribeiro, J. (2012). Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes research and clinical practice 98, 187-198. 3. Hansen, P.A., Nolte, L.A., Chen, M.M., and Holloszy, J.O. (1998). Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise. J Appl Physiol 85, 1218-1222. 4. Stephens, J.M., and Pilch, P.F. (1995). The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter. Endocrine reviews 16, 529-546. 5. Thorell, A., Hirshman, M.F., Nygren, J., Jorfeldt, L., Wojtaszewski, J.F., Dufresne, S.D., Horton, E.S., Ljungqvist, O., and Goodyear, L.J. (1999). Exercise and insulin cause GLUT-4 translocation in human skeletal muscle. The American journal of physiology 277, E733-741. 6. Joost, H.G., and Thorens, B. (2001). The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Molecular membrane biology 18, 247-256. 7. Thorens, B., and Mueckler, M. (2010). Glucose transporters in the 21st Century. American journal of physiology. Endocrinology and metabolism 298, E141-145. 8. Yu, C., Chen, Y., Cline, G.W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J.K., Cushman, S.W., Cooney, G.J., et al. (2002). Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. The Journal of biological chemistry 277, 50230-50236. 9. Goodyear, L.J., and Kahn, B.B. (1998). Exercise, glucose transport, and insulin sensitivity. Annual review of medicine 49, 235-261. 10. Hussey, S.E., McGee, S.L., Garnham, A., McConell, G.K., and Hargreaves, M. (2012). Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes. Diabetes, obesity metabolism 14, 768-771. 11. Samuel, V.T., Petersen, K.F., and Shulman, G.I. (2010). Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375, 2267-2277. 12. Malhotra, V., and Campelo, F. (2011). PKD regulates membrane fission to generate TGN to cell surface transport carriers. Cold Spring Harbor perspectives in biology 3. 13. Summers, S.A., Garza, L.A., Zhou, H., and Birnbaum, M.J. (1998). Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Molecular and cellular biology 18, 5457-5464. 14. Tanaka, S., Hayashi, T., Toyoda, T., Hamada, T., Shimizu, Y., Hirata, M., Ebihara, K., Masuzaki, H., Hosoda, K., Fushiki, T., et al. (2007). High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle. Metabolism: clinical and experimental 56, 1719-1728. 15. Kaufman, R.J. (2011). Beta-cell failure, stress, and type 2 diabetes. The New England journal of medicine 365, 1931-1933. 16. Shuldiner, A.R., Yang, R., and Gong, D.W. (2001). Resistin, obesity and insulin resistancethe emerging role of the adipocyte as an endocrine organ. The New England journal of medicine 345, 1345-1346. 17. Frosig, C., and Richter, E.A. (2009). Improved insulin sensitivity after exercise: focus on insulin signaling. Obesity (Silver Spring) 17 Suppl 3, S15-20. 18. Hayashi, T., Wojtaszewski, J.F., and Goodyear, L.J. (1997). Exercise regulation of glucose transport in skeletal muscle. The American journal of physiology 273, E1039-1051. 19. Douen, A.G., Ramlal, T., Rastogi, S., Bilan, P.J., Cartee, G.D., Vranic, M., Holloszy, J.O., and Klip, A. (1990). Exercise induces recruitment of the insulin-responsive glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. The Journal of biological chemistry 265, 13427-13430. 20. Coderre, L., Kandror, K.V., Vallega, G., and Pilch, P.F. (1995). Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. The Journal of biological chemistry 270, 27584-27588. 21. 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Effects of acute and chronic exercise on skeletal muscle glucose transport in aged rats. J Appl Physiol 78, 1750-1756.

Two Rivers :: essays research papers

Two Rivers, Wisconsin   Ã‚  Ã‚  Ã‚  Ã‚  If one were to travel 36 miles Southeast of Green Bay they would run into a small town known as Two Rivers. Two rivers is located on the coast of Lake Michigan. Two Rivers is surrounded on three sides by the majestic Lake Michigan. Not far from Two Rivers is its sister city Manitowoc.   Ã‚  Ã‚  Ã‚  Ã‚  French Canadians as well as the Chippewa Indians founded two Rivers. The Chippewa Indians called the area Neshotah that means â€Å"a junction of 2 rivers†, since the twin rivers join together before entering Lake Michigan. The Chippewa Indians also named the twin rivers. The West River is known as â€Å"Neshoto† meaning west, and the East river is â€Å"Mishicot† meaning east. Two Rivers is obviously named after these twin rivers. The rivers themselves are almost geographically the same. The rivers are split between the city capital that is located in the center of downtown, and then rejoin together right before they hit Lake Michigan. There is more than seven miles of clean and wide white sandy beaches along the city’s edges for the town’s people as well as the tourist to enjoy. Swimming, wind surfings, beach coming, or just even to take a brake and relax in the sun are just some of the things you can enjoy in Two Rivers. Not t o mention one of the biggest activities to enjoy is the fishing. Fishing charters is a major tourist attraction, the Kiwanis fishing derby brings anglers from throughout the Midwest. You can fish on or off shore in almost all of the four seasons. Not only are the Twin rivers a good resource for fishing they are a major and important resource for water. The rivers stream are usually calm and slow, which you could say it matches the way of life of Two Rivers.   Ã‚  Ã‚  Ã‚  Ã‚  Two Rivers is a town were the pace of life doesn’t get any slower. Its slow paced atmosphere and friendly townspeople make you feel like you are in the South. Trees line the quiet streets of the all American city. In the center of town are gracious old buildings that frame Central Park. Young and old gather here for festivals, or just to sit and talk. Band Concerts are also held in Central Park on a regular basis. Tourists shop at all the well-kept stores and are often greeted with a friendly smile. Two Rivers is a town were every body knows your name.

Macbeth †Character assessment Essay

The 3 witches have told Macbeth that he will become king. He tells this news to his wife, Lady Macbeth . She starts plotting the murder of Duncan, the king of Scotland. A messenger then arrives at Dunsinane telling her that Duncan will be visiting them that evening. In this scene Macbeth kills Duncan. Setting This play takes place on stage. The play is set in 1600’s in the Scottish Highlands. The stage is bare apart from a bench, a bucket and well, there is a backdrop of the castle at the rear of the stage. Character Profiles Macbeth Stunned at what he has just done Angry – with both himself and Lady Macbeth Becomes quite hysterical Pure shock Lady Macbeth Evil voice Devious Cunning Calm throughout 4th witch very clever & Very evil A soft blue light falls onto the stage with a white spot light on Lady Macbeth, the light including spot light turns green during Lady Macbeth’s speech. Lady Macbeth sits on bench at stage rear holding a pure black cat. (A black cat is connected with witches, Lady Macbeth is the 4th witch). Lady Macbeth starts to say her speech in an evil, cold, powerful, crackle of a voice. Here she will be talking to her cat rather than herself. Here she talks of the fatal bellman, this signifies death. An organ is playing in the background (organs are played at funerals, and signify death, a murder has just taken place). Macbeth backs onto the stage very slowly almost in a trance. He turns to face Lady Macbeth â€Å"I have done the deed.† – saying this like in complete shock but realisation as much to himself as to Lady Macbeth. Macbeth: â€Å"Did though not hear a noise?† Lady Macbeth: â€Å"The owl scream and the crickets cry† (Elizabethans would know These things represented Death) Lady Macbeth: Did thou not speak? Quick, Macbeth: When? Panicky, Lady Macbeth: Now. Shows Macbeth: As I descended? Nerves, Lady Macbeth: Ay. and. Macbeth: Hark! tension Who lies in the 2nd chamber? Lady Macbeth: Donalbain Macbeth: This is a sorry sight! (angry, shouting, he sees the blood). Lady Macbeth: A foolish thought to say (trying to calm him whilst putting her cat Down). Macbeth is now slumped on the floor with his head in his hands saying lines 21-25. Remaining slumped he says lines 26-30, but this time in a whisper. In these lines Macbeth talks about sleep. Only innocence is allowed to sleep, Macbeth cannot sleep anymore, for he is now evil. â€Å"Macbeth shall sleep no more!† Macbeth also talks about not being able to say amen, this is because he is no longer holy. Lady Macbeth stands to his right looking down on him, this shows her power over him. She says â€Å"Consider it not so deeply.† In an impatient, and almost dismissive voice. Macbeth: â€Å"Sleep no more Macbeth does murder sleep!† Lady Macbeth: â€Å"Why have you got these daggers? They must rest by Duncan.† Lady Macbeth grabs the daggers. Macbeth is afraid to go back to Duncan’s chamber, for he cannot bear to look at what he has done. â€Å"If Duncan do bleed then I shall place the daggers in the arms of the guards, for it will seem their guilt!† she says this in an evil yet excited whisper. Exits stage left, running. Her evil and cunning nature has now been fully exposed to the audience. (A loud knocking is heard, the knocking comes from speakers all around the theatre, so the audience is surrounded by the knocking). Macbeth: Is in complete hysteria cries line 59-60. The blood is represented by long red ribbons attached to his finger tips and his clothes. He walks over to the well and tries to wash the blood from his hands. â€Å"All Neptune’s great oceans could not wash these hands clean.† Neptune is God of water, so here Macbeth is saying all the water in the world could not wash the blood away. I think he was trying to wash away his crime and his guilt by getting rid of the blood, as this was just a visual reminder of the wrong he had done. He pretends to throw the blood stained water over the floor. A watery red light appears on the stage floor rippling with waves. Lady Macbeth appears back on stage with her hands out in front of her, her hands and clothing are soaked with blood (red ribbons). She holds her hands up to Macbeth’s face, he turns away from her. She starts to speak in an evil, cold, and angry voice â€Å"my hands are of your colour , but I shame to wear a heart so white.† The knocking starts again. Lady Mabeth spins around in a sudden panic, â€Å"I hear knocking!† Lady Macbeth says the rest of her speech in the same quick startled tone. This is the only time in the scene where LM shows her nerves. Macbeth in complete hysteria with tears running down his cheeks â€Å"Wake Duncan with your knocking, I would thou couldst!† At this point M’s weakness is most apparent, at this point I feel that he would be ready to confess all. Lady Macbeth and Macbeth exit stage right. Lady Macbeth now calm again, strides off confidently. Macbeth crawls off on his hands and knees. This shows the difference between Macbeth and Lady Macbeth, Macbeth is remorseful, guilt ridden and hysterical with disbelief. Lady Macbeth on the other hand is confident, calm, excited, and seems completely unfazed by the fact that she has helped murder her king. Her power over him is enormous, and makes you wonder whether Macbeth was in a trance to even be able to comprehend killing his king let alone actually doing it. At the end of the scene the lights suddenly go out the theatre is pitch black.

1) What Legislation Is in Place to Help You Administer Medication Safely? Give an Account of How This Affects Your Work.

Unit 616 Medication Questions 1) What legislation is in place to help you administer medication safely? Give an account of how this affects your work. The Medicines Act 1968 Regulates the supply and manufacture of medicines and defines the three categories of medicine: Prescription only, pharmacy medicines and general sales list. This affects my work in that it tells me which types of medicine I can simply pick up over the counter (for example, if someone I supported had a minor problem such as a cold, by consulting this legislation I would know which drugs I would be able to pick up without a prescription).It also categorises the medication which I currently administer and gives me an idea of how different types of medications are classified. For example, many times in the setting I work in, medication orders will be repeat prescriptions. For this, correct information must be supplied: name of service user, name and strength of medication and amount ordered sufficient for the time p eriod. The Misuse of Drugs Act 1972 Categorises banned substances into bands A, B, and C. This tells me that administering certain drugs would result in me breaking the law. It outlines what is legal to administer and what isn’t.Also this act outlines the legal requirement to store controlled drugs in locked cabinets and keep a record (controlled drugs register) of stock numbers, expiry dates etc. At our workplace we administer several controlled drugs such as diazepam, so this legislation affects me in the way that is outlines my legal responsibilities for storing and safely administering these drugs. Health and Safety at Work Act 1974 This act informs me of mine and my employer’s duties at work and tells me what is required of my employer to ensure the working environment is safe. Care Standards Act 2000Establishes national minimum standards in order to meet the needs of the people we support. For example, some of the people we support like to administer their own me dication and all information regarding their medication must be available for them to access at any time. Control of Substances Hazardous to Health Regulations 2002 This act outlines the requirements of employers to protect their employees from the hazards of substances used in the workplace. Medication comes under this act and it outlines principles for recording, safekeeping, handling and disposal of medicines, all things we deal with on a regular basis.

Free Essays on Internet Usage

"The Communications Decency Act is an amendment which prevents the information superhighway from becoming a computer "red light district." On June 14, 1995, by a vote of 84-16, the United States Senate passed the amendment. It is now being brought through the House of Representatives.1 The Internet is owned and operated by the government, which gives them the obligation to restrict the materials available through it. Though it appears to have sprung up overnight, the inspiration of free-spirited hackers, it in fact was born in Defense Department Cold War projects of the 1950s.2 The United States Government owns the Internet and has the responsibility to determine who uses it and how it is used. The government must control what information is accessible from its agencies. This material is not lawfully available through the mail or over the telephone, there is no valid reason these perverts should be allowed unimpeded on the Internet. Since our initiative, the industry has commendably advanced some blocking devices, but they are not a substitute for well-reasoned law.4 Because the Internet has become one of the biggest sources of information in this world, legislative safeguards are imperative. The government gives citizens the privilege of using the Internet, but it has never given them the right to use it. They seem to rationalize that the framers of the constitution planned & plotted at great length to make certain that above all else, the profiteering pornographer, the pervert and the pedophile must be free to practice their pursuits in the presence of children on a taxpayer created and subsidized computer network.3 People like this are the ones in the wrong. Taxpayer's dollars are being spent bringing obscene text and graphics into the homes of people all over the world." Computer, Internet, Privacy INTERNET REGULATION: POLICING CYBERSPACE The Inte... Free Essays on Internet Usage Free Essays on Internet Usage "The Communications Decency Act is an amendment which prevents the information superhighway from becoming a computer "red light district." On June 14, 1995, by a vote of 84-16, the United States Senate passed the amendment. It is now being brought through the House of Representatives.1 The Internet is owned and operated by the government, which gives them the obligation to restrict the materials available through it. Though it appears to have sprung up overnight, the inspiration of free-spirited hackers, it in fact was born in Defense Department Cold War projects of the 1950s.2 The United States Government owns the Internet and has the responsibility to determine who uses it and how it is used. The government must control what information is accessible from its agencies. This material is not lawfully available through the mail or over the telephone, there is no valid reason these perverts should be allowed unimpeded on the Internet. Since our initiative, the industry has commendably advanced some blocking devices, but they are not a substitute for well-reasoned law.4 Because the Internet has become one of the biggest sources of information in this world, legislative safeguards are imperative. The government gives citizens the privilege of using the Internet, but it has never given them the right to use it. They seem to rationalize that the framers of the constitution planned & plotted at great length to make certain that above all else, the profiteering pornographer, the pervert and the pedophile must be free to practice their pursuits in the presence of children on a taxpayer created and subsidized computer network.3 People like this are the ones in the wrong. Taxpayer's dollars are being spent bringing obscene text and graphics into the homes of people all over the world." Computer, Internet, Privacy INTERNET REGULATION: POLICING CYBERSPACE The Inte...

Taking Up Arms Against Slavery by John Brown Essay

Taking Up Arms Against Slavery by John Brown - Essay Example ality and exclusion from the political system there may sometimes be no other way to change things. I believe that modern observers would agree with John Brown’s message if he meant the blood of soldiers, but disagree if the blood of civilians was involved. One of the major influences that would affect a modern observer’s view on whether blood should or should not be spent in a political cause is terrorism. The world changed on September 11, 2001, when a group of terrorists who saw themselves as freedom fighters trying to strike a blow against a country that was, in their views, making the world a less holy place, crashed two planes into the Twin Towers and killed thousands of people who were civilians that were, as much as one could be, completely disassociated with Western-Arab conflict. Since then suicide tactics have risen to prominence as a tool for radical Islamists everywhere, much to the distaste of observers everywhere else, who now find knowing killing oneâ₠¬â„¢s self to kill others despicable. This Event also brought into the American mind how truly awful it is when civilians are killed in conflict, which is an inevitable consequence of most wars, which has led to massive discontent in America and around the rest of the world when Western governments take actions that could and do cause civilian casualties. This has led those countries to develop new technologies and completely change the way they conduct warfare to reduce civilian casualties. This, coupled with a largely negative view of the decade long war in Iraq, means that people today tend to have a more negative view of warfare generally – they recognize better that in any war civilians will suffer and die, which usually just escalates a conflict, causing things to get worse. In this light, a modern observer would probably disagree with Brown’s words – they would say that people should find a way other than killing and being killed to achieve their ends. On the other hand, modern people do recognize that sometimes there may be no other way to change an unjust political system than through violence, and sometimes people who are unwilling to use violence will simply continue to be the victims of it, like what probably would have occurred in Libya had the population not armed themselves. The Arab Spring, as it is called, has been hailed as an amazing demonstration of a people’s willingness to fight for their freedom, even when the fight turns bloody, and indicates that modern people still can understand fighting and dying for a cause. There are several factors that help these uprisings overcome the reservations that people have about warfare that were outlined above. The first, and probably most important, is that the people were acting largely in self defense. They were an unarmed populace being brutalized by an armed body, and had to take up arms to defend themselves. The second is

Five structural differences between the farmhouse in Tales from the Assignment

Five structural differences between the farmhouse in Tales from the Green Valley and the medieval cruk house - Assignment Example The Tipi in both accounts is a conical shape; however, several material differences prevail. The animal skin and wooden poles in Green Valley presents a much difference from medieval Cruck, which takes a more nomadic pastoralist perspective. The skills, tools and technology used in both explorations presents a structural replication in thatching. The primitive dwelling pit house in Green valley has a grass roof meant to protect belonging from any environmental harm. The extreme weather in the medieval period; however, brings into light a series of materials such as wood and sticks that represent cultural beliefs. The dazzling social appearance of igloo in the contemporary world presents digital imagination. Nevertheless, in Green Valley igloo and earth lodges only shape presents a notable difference. Apparently, both have the same materials to put up the structure. Arguably, both accounts have the best proclamation of past construction features. Most importantly, the tales can form a primary step to counter faulty digital discoveries (Suggett